Human beings have coexisted on the planet with billions of microbes since the beginning of time, and fortunately only a relatively small fraction of those successfully managed to invade, persist and cause disease. This course reviews the concepts of microbiology needed for the Step 1 Exam.
- Mechanisms of Microbial Pathogenesis, Genetics and Drug Resistance
- Identify the basic anatomy and physiology of the major microbial groups.
- List the important flora and understand how they affect diagnosis.
- Describe the major mechanisms of pathogenesis of each of the major microbial groups.
- Understand the mechanisms of action of the major bacterial toxins.
- Define the mechanisms of horizontal genetic transfer in bacteria: transformation, conjugation, and transduction.
- Explain the role of transposons in the formation of multi-drug-resistant plasmids.
- Identify the major mechanisms of bacterial drug resistance.
- Describe common laboratory techniques for sterilization and disinfection, and drug sensitivity testing
- Describe the anatomy and physiology of the major categories of prokaryotes.
- Medically Important Bacteria
- Distinguish the major types of bacterial disease.
- Identify the causal agent from symptomatic, diagnostic, and epidemiologic clues.
- Answer basic science questions about the agent concerning anatomy, physiology, and pathogenesis.
- Medically Important Viruses
- Explain the anatomy and life cycles of major human virus pathogens.
- Interpret serological findings in the diagnosis of viral hepatitis.
- Describe the diagnosis and treatment of herpes virus infections.
- Distinguish between genetic drift and shift and be able to explain their roles in epidemiology.
- Medically Important Fungi
- Identify and describe the basic structures of fungi from microscopic.
- Differentiate the structure, chemistry, and physiology of the fungi from other microbial groups.
- Diagnose and recommend therapies for the common fungal pathogens in the US.
- Explain the mechanisms of action of the major anti-fungal drugs.
- Medically Important Parasites
- Diagnose and treat the major parasitic diseases.
- Describe the means of infection for the major parasites.
- Identify the scientific and common names for parasites and their diseases.
- Explain the relationship between the Plasmodium life cycle and the pathogenesis of malaria.