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Home Forums Stump the Chump Doubt on CVS PathoPharmacology Reply To: Doubt on CVS PathoPharmacology

  • sai

    June 30, 2020 at 3:28 pm

    It’s still confusing me. ACh normally causes vasodilation via M3 receptors(activation of M3 on vascular endothelial cells causes increased synthesis of nitric oxide, which diffuses to adjacent vascular smooth muscle cells and causes their relaxation and vasodilation). So if there is dysfunction with NO production, then why does increased vagal tone cause Vasoconstriction. It should rather cause nothing. And even if it causes Vasoconstriction, then which receptors are involved now because M3 causes vasodilation.<div>